Manufacturer of Sinemet Tablet
Sinemet tablet is manufactured by MERCK. It is an American pharmaceutical company and one of the largest pharmaceutical companies in the world. The company was established in 1891 by George Merck . It is currently one of the world's seven largest pharmaceutical companies by market capitalization and revenue. Merck also publishes The Merck Manuals (reference book), Merck Manual Of Diagnosis And Therapy (world's best-selling medical textbook), and The Merck Index ( a compendium of chemical compounds). In 2012 the company received the "Facility of the Year"-Category Winner for Facility Integration Award for the Vaccine Bulk Manufacturing Facility (VBF) Program of Projects.
Contents of Sinemet Tablet
Sinemet tablet is a combination of carbidopa and levodopa for the treatment of Parkinson's disease and dopamine-responsive dystonia (DRD).Main reason for Parkinson's disease is associated with low levels of a chemical called dopamine in the brain.
Levodopa is a precursor of dopamin turned in to dopamine in the body and therefore increases levels of the dopamin.Levodopa is converted to dopamine by a naturally occurring enzyme called DOPA decarboxylase.This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier.
Centrally acting dopamine improves the symptoms of Parkinson's disease;but peripherally acting dopamine can causes nausea and vomiting. For avoiding this problem levodopa is usually administered in combination with a DOPA decarboxylase inhibitor (DDCI),eg: carbidopa, which is very polar and cannot cross the blood brain barrier, however prevents peripheral conversion of levodopa to dopamine and thereby reduces the unwanted peripheral side effects of levodopa. Use of carbidopa also decrease the dose of levodopa .
Centrally acting dopamine improves the symptoms of Parkinson's disease;but peripherally acting dopamine can causes nausea and vomiting. For avoiding this problem levodopa is usually administered in combination with a DOPA decarboxylase inhibitor (DDCI),eg: carbidopa, which is very polar and cannot cross the blood brain barrier, however prevents peripheral conversion of levodopa to dopamine and thereby reduces the unwanted peripheral side effects of levodopa. Use of carbidopa also decrease the dose of levodopa .
Usage of Sinemet Tablet
Levodopa is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease.
Side Effects of Sinemet Tablet
Common side effects include dizziness, nausea, vomiting, trouble sleeping, and headache, dry mouth, loss of appetite, heartburn, diarrhea, constipation, blurred vision ,sneezing, stuffy nose, cough, or other cold symptoms,sleep problems (insomnia), strange dreams,muscle pain, numbness or tingly feeling.
If your experiencing any of the following side effects consult your doctor immediately,
- signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
- restless muscle movements in your eyes, tongue, jaw, or neck.
- worsening of tremors (uncontrolled shaking).
- high fever, stiff muscles, sweating, fast or uneven heartbeats, rapid breathing, feeling like you might pass out.
- seizure (convulsions).
- painful or difficult urination.
- severe nausea, vomiting, or diarrhea.
- uneven heart rate or fluttering in your chest.
- confusion, hallucinations, anxiety, agitation, depressed mood.
- chest pain , pain spreading to the arm or shoulder.
Sinemet Tablets are available in different doses such as Sinemet 12.5mg/50mg, 10mg/100mg, 25mg/100mg and 25mg/250mg Tablets.
mode of administration :Oral route
Initial dose of Sinemet tablet is 25 mg/100 mg' three times a day.Further, dose will be
increased according to the patient condition.
Safety and effectiveness in paediatric patients have not been established. Use of the drug in patients below the age of 18 is not recommended.
FDA pregnancy
Sinemet tablet falls under catagory C of US FDA.The effects of 'Sinemet' on human pregnancy are unknown, both levodopa and combinations of carbidopa and levodopa have caused visceral and skeletal malformations in rabbits.Therefore, the use of 'Sinemet' in pregnant women is contraindicated.
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