Gentamicin -Uses ,dosage , side effects

GENTAMICIN is an antibiotic under the class of Aminoglycoside and it is an important drug for the treatment of many serious gram-negative bacillary infections and usually is the aminoglycoside of first choice because of its low cost and reliable activity against all but the most resistant gram-negative aerobes. Gentamicin is given parenterally, ophthalmically,and topically.
Availability of Gentamicin
 Eye drops 0.3% w/v, cream 15g (0.1%w/w); INJECTION 2 ml ampoule (40 mg/ml),2 and 10 ml vials (40 mg/ml).

Amikacin-Uses and Side effects

AMIKACIN is an antibiotic under the class of aminoglycosides with amino sugars in glycosidic linkages. Amikacin is a semisynthetic product and used to treat conditions such as Bacterial infections, uncomplicated urinary tract infections, severe gram-negative infections resistant to gentamicin and tobramycin, and short term treatment of serious infections caused by Pseudomonas species, Escherichia coli, species of indole-positive and indole negative, Proteus, Klebsiella, Enterobacter, Serratia, Salmonella, Shigella and Acinetobacter. Get to know how Amikacin works, its side effects, precautions, interactions, and contraindications.

How does Amikacin work?

Amikacin has the capacity to kill the bacteria by binding to 30S ribosomes and inhibit bacterial protein synthesis. The drug penetrates the bacterial cell membrane through pores.

Amikacin has concentration-dependent bactericidal activity against Gram-negative aerobic bacteria, anaerobic bacteria are universally resistant because aminoglycoside transport into cells is oxygen-dependent.